Phytochemical Analysis and Evaluation of Biological Activity of Lawsonia inermis Seeds Related to Alzheimer's Disease.

ABSTRACT: Using Lawsonia inermis L. (henna) seeds has been frequently recommended for the improvement of memory in Iranian Traditional Medicine (ITM). In this respect, different fractions of the plant were prepared and evaluated for their in vitro biological assays related to Alzheimer's disease (AD), including acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activity as well as metal chelating ability and DPPH antioxidant activity. The dichloromethane and ethyl acetate fractions were able to inhibit the BChE selectively with IC₅₀ values of 113.47 and 124.90 μg/mL, respectively, compared with donepezil as the reference drug (IC₅₀ = 1.52 μg/mL). However, all fractions were inactive toward AChE. Phytochemical analysis of the dich

SUBMITTER: Balaei-Kahnamoei M 

PROVIDER: S-EPMC8313326 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature