Consensus Guidelines on Rodent Models of Restless Legs Syndrome.

ABSTRACT: Restless legs syndrome (RLS) is a chronic sensorimotor disorder diagnosed by clinical symptoms. It is challenging to translate the diagnostic self-reported features of RLS to animals. To help researchers design their experiments, a task force was convened to develop consensus guidelines for experimental readouts in RLS animal models. The RLS clinical diagnostic criteria were used as a starting point. After soliciting additional important clinical features of RLS, a consensus set of methods and outcome measures intent on capturing these features-in the absence of a face-to-face interview-was generated and subsequently prioritized by the task force. These were, in turn, translated into corresponding methods and outcome measures for research on laboratory rats and mice and used to generate th

SUBMITTER: Salminen AV 

PROVIDER: S-EPMC8313425 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature