MiR-301 regulates the SIRT1/SOX2 pathway via CPEB1 in the breast cancer progression.

ABSTRACT: Breast cancer, the most common malignant tumor in women, has become a worldwide burden for family and society. MicroRNAs (miRNAs or miRs) are recognized as critical mediators of cancer-related processes, since they have the ability to coordinately suppress multiple target genes. In this study, we aim to find out specific miRNAs involved in the progression of breast cancer and explore the underlying molecular mechanism. Bioinformatics analysis suggested miR-301 as a differentially overexpressed miRNA in breast cancer, which was confirmed by expression determination. Functional assays were employed to explore the effect of miR-301 and its downstream effectors cytoplasmic polyadenylation element-binding protein 1 (CPEB1), SIRT1, and SOX2 on malignant phenotypes of breast cancer. The interacti

SUBMITTER: Jia Y 

PROVIDER: S-EPMC8313741 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature