CXCR5⁺CD8⁺ T Cells Shape Antibody Responses In Vivo Following Protein Immunisation and Peripheral Viral Infection.

ABSTRACT: Crosstalk between T and B cells is crucial for generating high-affinity, class-switched antibody responses. The roles of CD4⁺ T cells in this process have been well-characterised. In contrast, regulation of antibody responses by CD8⁺ T cells is significantly less defined. CD8⁺ T cells are principally recognised for eliciting cytotoxic responses in peripheral tissues and forming protective memory. However, recent findings have identified a novel population of effector CD8⁺ T cells that co-opt a differentiation program characteristic of CD4⁺ T follicular helper (Tfh) cells, upregulate the chemokine receptor CXCR5 and localise to B cell follicles. While it has been shown that CXCR5⁺CD8⁺ T cells mediate the removal of

SUBMITTER: Tyllis TS 

PROVIDER: S-EPMC8314013 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature