Correlation Between Surrogate End Points and Overall Survival in a Multi-institutional Clinicogenomic Cohort of Patients With Non-Small Cell Lung or Colorectal Cancer.

ABSTRACT:

Importance

Contemporary observational cancer research requires associating genomic biomarkers with reproducible end points; overall survival (OS) is a key end point, but interpretation can be challenging when multiple lines of therapy and prolonged survival are common. Progression-free survival (PFS), time to treatment discontinuation (TTD), and time to next treatment (TTNT) are alternative end points, but their utility as surrogates for OS in real-world clinicogenomic data sets has not been well characterized.

Objective

To measure correlations between candidate surrogate end points and OS in a multi-institutional clinicogenomic data set.

Design, setting, and participants

A retrospective cohort study was conducted of patients with non-small cell lung cancer (NSCLC) or

SUBMITTER: Kehl KL 

PROVIDER: S-EPMC8314138 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature