Genetic Variants Associated With Intraparenchymal Hemorrhage Progression After Traumatic Brain Injury.

ABSTRACT:

Importance

Intracerebral hemorrhage progression is associated with unfavorable outcome after traumatic brain injury (TBI). No effective treatments are currently available. This secondary injury process reflects an extreme form of vasogenic edema and blood-brain barrier breakdown. The sulfonylurea receptor 1-transient receptor potential melastatin 4 (SUR1-TRPM4) cation channel is a key underlying mechanism. A phase 2 trial of SUR1-TRPM4 inhibition in contusional TBI is ongoing, and a phase 3 trial is being designed. Targeted identification of patients at increased risk for hemorrhage progression may inform prognostication, trial design (including patient selection), and ultimately treatment response.

Objective

To determine whether ABCC8 (SUR1) and TRPM4 genetic variability ar

SUBMITTER: Jha RM 

PROVIDER: S-EPMC8314141 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature