Annual Research Review: Defining and treating pediatric treatment-resistant depression.

ABSTRACT:

Background

Adolescent major depressive disorder (MDD) is a significant health problem, associated with substantial morbidity, cost, and mortality. Depression is a significant risk factor for suicide, which is now the second leading cause of death in young people. Up to twenty per cent of adolescents will experience MDD before adulthood, and while a substantial proportion will improve with standard-of-care treatments (psychotherapy and medication), roughly one third will not.

Methods

Here, we have reviewed the literature in order to discuss the concept of treatment-resistant depression (TRD) in adolescence, examine risk factors, diagnostic difficulties, and challenges in evaluating symptom improvement, and providing guidance on how to define adequate medication and psychother

SUBMITTER: Dwyer JB 

PROVIDER: S-EPMC8314167 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature