Seizure Prophylaxis After Spontaneous Intracerebral Hemorrhage.

ABSTRACT:

Importance

Limited evidence is available concerning optimal seizure prophylaxis after spontaneous intracerebral hemorrhage (sICH).

Objective

To evaluate which of 4 seizure prophylaxis strategies provides the greatest net benefit for patients with sICH.

Design, setting, and participants

This decision analysis used models to simulate the following 4 common scenarios: (1) a 60-year-old man with low risk of early (≤7 days after stroke) (10%) and late (3.6% or 9.8%) seizures and average risk of short- (9%) and long-term (30%) adverse drug reaction (ADR); (2) an 80-year-old woman with low risk of early (10%) and late (3.6% or 9.8%) seizures and high short- (24%) and long-term (80%) ADR risks; (3) a 55-year-old man with high risk of early (19%) and late (34.8% or 46.2%) seiz

SUBMITTER: Jones FJS 

PROVIDER: S-EPMC8314179 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature