An investigation of the relation between catalase C262T gene polymorphism and catalase enzyme activity in leukemia patients.

ABSTRACT:

Introduction

Catalase (CAT), an antioxidant enzyme, catalyzes conversion of hydrogen peroxide to water and molecular oxygen, protecting cells against oxidative stress. The aim of this study was to investigate the possible association between CAT C262T polymorphism in the promoter region of the CAT gene and leukemia risk and to determine the relationship between CAT genotypes and CAT enzyme activities.

Material and methods

Genotypes of 102 cases and 112 healthy controls' genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism methods. Catalase activity was measured with the method of Aebi.

Results

The frequencies of the T allele among the cases and controls were 28.4% and 25.9%, respectively (p = 0.75)

SUBMITTER: Eras N 

PROVIDER: S-EPMC8314395 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature