Microheart: A microfluidic pump for functional vascular culture in microphysiological systems.

ABSTRACT: Advances in microphysiological systems have prompted the need for long-term cell culture under physiological flow conditions. Conventional laboratory pumps typically lack the ability to deliver cell culture media at the low flow rates required to meet the physiological ranges of fluid flow, and are often pulsatile or require flow reversal. Here, a microfluidic-based pump is presented, which allows for the controlled delivery of media for vascular microphysiological applications. The performance of the pump was characterized in a range of microfluidic systems, including straight channels of varying dimensions and self-assembled microvascular networks. A theoretical framework was developed based on lumped element analysis to predict the performance of the pump for different fluidic configura

SUBMITTER: Offeddu GS 

PROVIDER: S-EPMC8314430 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature