Amplification of oxidative stress with lycorine and gold-based nanocomposites for synergistic cascade cancer therapy.

ABSTRACT:

Background

Despite advances of surgery and neoadjuvant chemotherapy during the past few decades, the therapeutic efficacy of current therapeutic protocol for osteosarcoma (OS) is still seriously compromised by multi-drug resistance and severe side effects. Amplification of intracellular oxidative stress is considered as an effective strategy to induce cancer cell death. The purpose of this study was to develop a novel strategy that can amplify the intracellular oxidative stress for synergistic cascade cancer therapy.

Methods and results

A novel nanocomposite, composed of folic acid (FA) modified mesoporous silica-coated gold nanostar (GNS@MSNs-FA) and traditional Chinese medicine lycorine (Ly), was rationally designed and developed. Under near-infrared (NIR) irradiation, the

SUBMITTER: Hu H 

PROVIDER: S-EPMC8314456 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature