Transcriptional landscape of PTEN loss in primary prostate cancer.

ABSTRACT:

Background

PTEN is the most frequently lost tumor suppressor in primary prostate cancer (PCa) and its loss is associated with aggressive disease. However, the transcriptional changes associated with PTEN loss in PCa have not been described in detail. In this study, we highlight the transcriptional changes associated with PTEN loss in PCa.

Methods

Using a meta-analysis approach, we leveraged two large PCa cohorts with experimentally validated PTEN and ERG status by Immunohistochemistry (IHC), to derive a transcriptomic signature of PTEN loss, while also accounting for potential confounders due to ERG rearrangements. This signature was expanded to lncRNAs using the TCGA quantifications from the FC-R2 expression atlas.

Results

The signatures indicate a strong activation

SUBMITTER: Imada EL 

PROVIDER: S-EPMC8314517 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature