Elevated plasma succinate levels are linked to higher cardiovascular disease risk factors in young adults.

ABSTRACT:

Background

Succinate is produced by both host and microbiota, with a key role in the interplay of immunity and metabolism and an emerging role as a biomarker for inflammatory and metabolic disorders in middle-aged adults. The relationship between plasma succinate levels and cardiovascular disease (CVD) risk in young adults is unknown.

Methods

Cross-sectional study in 100 (65% women) individuals aged 18-25 years from the ACTIvating Brown Adipose Tissue through Exercise (ACTIBATE) study cohort. CVD risk factors, body composition, dietary intake, basal metabolic rate, and cardiorespiratory fitness were assessed by routine methods. Plasma succinate was measured with an enzyme-based assay. Brown adipose tissue (BAT) was evaluated by positron emission tomography, and circulating o

SUBMITTER: Osuna-Prieto FJ 

PROVIDER: S-EPMC8314524 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature