Identification of ferroptosis genes in immune infiltration and prognosis in thyroid papillary carcinoma using network analysis.

ABSTRACT:

Background

Papillary thyroid carcinoma (PTC) is the most common thyroid cancer. While many patients survive, a portion of PTC cases display high aggressiveness and even develop into refractory differentiated thyroid carcinoma. This may be alleviated by developing a novel model to predict the risk of recurrence. Ferroptosis is an iron-dependent form of regulated cell death (RCD) driven by lethal accumulation of lipid peroxides, is regulated by a set of genes and shows a variety of metabolic changes. To elucidate whether ferroptosis occurs in PTC, we analyse the gene expression profiles of the disease and established a new model for the correlation.

Methods

The thyroid carcinoma (THCA) datasets were downloaded from The Cancer Genome Atlas (TCGA), UCSC Xena and MisgDB, and incl

SUBMITTER: Lin R 

PROVIDER: S-EPMC8314640 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature