Molecular imaging of inflammation crosstalk along the cardio-renal axis following acute myocardial infarction.

ABSTRACT: Rationale: Acute myocardial infarction (MI) triggers a systemic inflammatory response including crosstalk along the heart-kidney axis. We employed radionuclide-based inflammation-targeted whole-body molecular imaging to identify potential cardio-renal crosstalk after MI in a translational setup. Methods: Serial whole-body positron emission tomography (PET) with the specific CXCR4 ligand ⁶⁸Ga-Pentixafor was performed after MI in mice. Tracer retention in kidneys and heart was compared to hematopoietic organs to evaluate systemic inflammation, validated by ex vivo analysis and correlated with progressive contractile dysfunction. Additionally, 96 patients underwent ⁶⁸Ga-Pentixafor PET within the first week after MI, for systems-based image analysis a

SUBMITTER: Werner RA 

PROVIDER: S-EPMC8315063 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature