Common Variants in NUS1 and GP2 Genes Contributed to the Risk of Gestational Diabetes Mellitus.

ABSTRACT:

Background

Recently, NUS1 and GP2 genes were reported to be associated with the risk of type 2 diabetes (T2D) in a Japanese population. Given the sharing of pathogenic contribution from genetic factors between T2D and gestational diabetes mellitus (GDM), we conducted the study to systematically examine the relationship of NUS1 and GP2 genes with the susceptibility to GDM in Chinese Han population.

Methods

A total of 4,250 subjects comprised of 1,282 patients with GDM and 2,968 controls were recruited, and 20 tag single nucleotide polymorphisms (SNPs) (10 from NUS1 and 10 from GP2) were selected for genotyping. Association analyses were conducted for GDM and its related biomedical indexes including fasting glucose and HbA1c levels.

SUBMITTER: Zhang T 

PROVIDER: S-EPMC8315097 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature