High Rates of Recurrent Tuberculosis Disease: A Population-level Cohort Study.

ABSTRACT:

Background

Retreatment tuberculosis (TB) disease is common in high-prevalence settings. The risk of repeated episodes of recurrent TB is unknown. We calculated the rate of recurrent TB per subsequent episode by matching individual treatment episodes over a period of 13 years.

Methods

All recorded TB episodes in Cape Town between 2003 and 2016 were matched by probabilistic linkage of personal identifiers. Among individuals with a first episode notified in Cape Town and who completed their prior treatment successfully we estimated the recurrence rate stratified by subsequent episode and HIV status. We adjusted person-time to background mortality by age, sex, and HIV status.

Results

A total of 292 915 TB episodes among 263 848 individuals were included. The rate of recur

SUBMITTER: Hermans SM 

PROVIDER: S-EPMC8315130 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature