Low gestational vitamin D level and childhood asthma are related to impaired lung function in high-risk children.

ABSTRACT:

Background

Lung function impairment in early life often persists into adulthood. Therefore, identifying risk factors for low childhood lung function is crucial.

Objective

We examined the effect of 25-hydroxyvitamin D (25[OH]D) level and childhood asthma phenotype on childhood lung function in the Vitamin D Antenatal Asthma Reduction Trial (VDAART).

Methods

The 25(OH)D level was measured at set time points in mothers during pregnancy and in children during early life. On the basis of parental reports, children were categorized into 3 clinical phenotypes: asymptomatic/infrequent wheeze, early transient wheeze, and asthma at age 6 years. Lung function was assessed with impulse oscillometry at ages 4, 5, and 6 years and with spirometry at ages 5 and 6 years.

Results

SUBMITTER: Knihtila HM 

PROVIDER: S-EPMC8315297 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature