MicroCT Imaging of Heart Valve Tissue in Fluid.

ABSTRACT:

Background

Heart valve computational models require high quality geometric input data, commonly obtained using micro-computed tomography. Whether in the open or closed configuration, most studies utilize dry valves, which poses significant challenges including gravitational and surface tension effects along with desiccation induced mechanical changes.

Objective

These challenges are overcome by scanning in a stress-free configuration in fluid. Utilizing fluid backgrounds however reduces overall contrast due to the similar density of fluid and tissue.

Methods

The work presented here demonstrates imaging of the mitral valve by utilizing an iodine-based staining solution to improve the contrast of valve tissue against a fluid background and investigates the role of stain

SUBMITTER: Stephens SE 

PROVIDER: S-EPMC8315378 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature