Influence of Acid Blockade on the Aerodigestive Tract Microbiome in Children With Cystic Fibrosis.

ABSTRACT:

Background

Acid blockade is commonly prescribed in patients with cystic fibrosis (CF). Growing concerns, however, exist about its possible role in the pathophysiology of pulmonary infections. We aimed to investigate if acid blockade alters esophageal and respiratory microbiota leading to dysbiosis and inflammation.

Methods

We performed a cross sectional study of children with CF who were either prescribed acid blockade or not. Samples from the gastrointestinal and respiratory tracts were obtained and microbiome analyzed. Mixed effect models were used to compare outcomes between cohorts and across sampling sites. A random subject intercept was included to account for the multiple sampling sites per individual.

Results

A cohort of 25 individuals, 44% girls with median a

SUBMITTER: Khalaf RT 

PROVIDER: S-EPMC8315410 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature