A population-based genomic epidemiological study of the source of tuberculosis infections in an emerging city: Shenzhen, China.

ABSTRACT:

Background

Tuberculosis (TB) in emerging cities is often a disease of recent immigrants, and understanding this epidemiology is crucial for designing effective control and prevention strategies.

Methods

We conducted a retrospective population-based genomic epidemiological study of culture-positive pulmonary TB patients diagnosed between June 2014 and November 2017 in the Bao'an District of Shenzhen, a Chinese city with dramatic recent growth. After whole genome sequencing, transmission clusters were defined as strains differing by no more than 12 SNPs.

Findings

Of 1696 culture-positive TB patients, 93•8% (1591/1696) were migrants, with 51•6% (821/1591) employed in housekeeping or unemployed. Of the 1460 migrants with known residence time, 47•7% (697/1460) developed TB

SUBMITTER: Yang T 

PROVIDER: S-EPMC8315418 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature