Multimodal neuroimaging markers of variation in cognitive ability in older HIV+ men.

ABSTRACT:

Objective

This study used converging methods to examine the neural substrates of cognitive ability in middle-aged and older men with well-controlled HIV infection.

Methods

Seventy-six HIV+ men on antiretroviral treatment completed an auditory oddball task and an inhibitory control (Simon) task while time-locked high-density EEG was acquired; 66 had usable EEG data from one or both tasks; structural MRI was available for 43. We investigated relationships between task-evoked EEG responses, cognitive ability and immunocompromise. We also explored the structural correlates of these EEG markers in the sub-sample with complete EEG and MRI data (N = 27).

Results

EEG activity was associated with cognitive ability at later (P300) but not earlier stages of both tasks. Only the

SUBMITTER: Fernandez Cruz AL 

PROVIDER: S-EPMC8315526 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature