A novel stochastic simulation approach enables exploration of mechanisms for regulating polarity site movement.

ABSTRACT: Cells polarize their movement or growth toward external directional cues in many different contexts. For example, budding yeast cells grow toward potential mating partners in response to pheromone gradients. Directed growth is controlled by polarity factors that assemble into clusters at the cell membrane. The clusters assemble, disassemble, and move between different regions of the membrane before eventually forming a stable polarity site directed toward the pheromone source. Pathways that regulate clustering have been identified but the molecular mechanisms that regulate cluster mobility are not well understood. To gain insight into the contribution of chemical noise to cluster behavior we simulated clustering using the reaction-diffusion master equation (RDME) framework to account for m

SUBMITTER: Ramirez SA 

PROVIDER: S-EPMC8315557 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature