A Preliminary Randomized Controlled Trial of Different Treatment Regimens for Melancholic Depression.

ABSTRACT:

Background

Fluoxetine, bupropion, cognitive behavioral therapy (CBT), and physical therapies (modified electroconvulsive treatment or repetitive transcranial magnetic stimulation) can be used to manage melancholic depression.

Objective

To compare the efficacy and safety of various treatments in patients with melancholic depression.

Methods

This was a preliminary multicenter randomized controlled trial that included patients with depression in their first or recurrent acute episode between September 2016 and June 2019, and randomized to fluoxetine, fluoxetine+CBT, fluoxetine+bupropion, and fluoxetine+bupropion+brain stimulation. The primary endpoint was the decrease in the 17-item Hamilton Depression Rating Scale (17-HDRS). The secondary endpoint included the scores fr

SUBMITTER: Wang Y 

PROVIDER: S-EPMC8315770 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature