Systematic Understanding of the Mechanism of Baicalin against Gastric Cancer Using Transcriptome Analysis.

ABSTRACT:

Background

Gastric cancer (GC) is the most common type of cancer. It is highly malignant and is characterized by rapid and uncontrolled growth. The antitumour activity of Baicalin was studied in multiple cancers. However, its mechanism of action has not been fully elucidated. We provided a systematic understanding of the mechanism of action of baicalin against GC using a transcriptome analysis of RNA-seq.

Methods

Human GC cells (SGC-7901) were exposed to 200 μg/ml baicalin for 24 h. RNA-seq with a transcriptome, Gene Ontology (GO), and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were used to identify the antitumour effects of baicalin on SGC-7901 cells in vitro. A protein-protein interaction (PPI) network of differentially expressed genes (DEGs)

SUBMITTER: Zhou W 

PROVIDER: S-EPMC8315853 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature