Influence of Fluconazole Administration on Gut Microbiome, Intestinal Barrier, and Immune Response in Mice.

ABSTRACT: Antibiotics that can treat or prevent infectious diseases play an important role in medical therapy. However, the use of antibiotics has potentially negative effects on the health of the host. For example, antibiotics use may affect the host's immune system by altering the gut microbiota. Therefore, the aim of the study was to investigate the influence of antifungal (fluconazole) treatment on the gut microbiota and immune system of mice. Results showed that the gut microbial composition of mice receiving fluconazole treatment was significantly changed after the trial. Fluconazole did not affect the relative abundance of bacteria but significantly reduced the diversity of bacterial flora. In the bacteriome, Firmicutes and Proteobacteria significantly increased, while Bacter

SUBMITTER: Heng X 

PROVIDER: S-EPMC8315907 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature