Molecular Epidemiology of Third-Generation-Cephalosporin-Resistant Enterobacteriaceae in Southeast Queensland, Australia.

ABSTRACT: Third-generation cephalosporin-resistant (3GC-R) Enterobacteriaceae represent a major threat to human health. Here, we captured 288 3GC-R Enterobacteriaceae clinical isolates from 264 patients presenting at a regional Australian hospital over a 14-month period. In addition to routine mass spectrometry and antibiotic sensitivity testing, isolates were examined using rapid (∼40-min) real-time PCR assays targeting the most common extended-spectrum β-lactamases (ESBLs; bla_CTX-M-1 and bla_CTX-M-9 groups, plus bla_TEM, bla_SHV, and an internal 16S rRNA gene control). AmpC CMY β-lactamase (bla_CMY) prevalence was also examined. Escherichia coli (80.2%) and Klebsiella pneumoniae (17.0%

SUBMITTER: Stewart AG 

PROVIDER: S-EPMC8315908 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature