Physiological Responses of Aspergillus niger Challenged with Itraconazole.

ABSTRACT: Aspergillus niger is an opportunistic pathogen commonly found in a variety of indoor and outdoor environments. An environmental isolate of A. niger from a pig farm was resistant to itraconazole, and in-depth investigations were conducted to better understand cellular responses that occur during growth when this pathogen is exposed to an antifungal. Using a combination of cultivation techniques, antibiotic stress testing, and label-free proteomics, this study investigated the physiological and metabolic responses of A. niger to sublethal levels of antifungal stress. Challenging A. niger with itraconazole inhibited growth, and the MIC was estimated to be > 16 mg · liter^-1 Through the proteome analysis, 1,305 unique proteins were identified. During growt

SUBMITTER: Poulsen JS 

PROVIDER: S-EPMC8316071 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature