Porcine Hemagglutinating Encephalomyelitis Virus Infection In Vivo and Ex Vivo.

ABSTRACT: Porcine hemagglutinating encephalomyelitis virus (PHEV) is a betacoronavirus that causes vomiting and wasting disease and/or encephalomyelitis in suckling pigs. This study characterized PHEV infection, pathogenesis, and immune response in cesarean-derived, colostrum-deprived (CDCD) neonatal pigs. Infected animals developed mild respiratory, enteric, and neurological clinical signs between 2 to 13 days postoronasal inoculation (dpi). PHEV did not produce viremia, but virus shedding was detected in nasal secretions (1 to 10 dpi) and feces (2 to 7 dpi) by reverse transcriptase quantitative PCR (RT-qPCR). Viral RNA was detected in all tissues except liver, but the detection rate and RT-qPCR threshold cycle (C_T ) values decreased over time. The highest concentration of virus w

SUBMITTER: Mora-Diaz JC 

PROVIDER: S-EPMC8316118 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature