Analyzing Possible Native Functions of the Quinolone Resistance Gene qnr in Vibrio vulnificus.

ABSTRACT: The worldwide distribution of qnr genes found on plasmids and their presence on the chromosomes of aquatic bacteria, such as Vibrio vulnificus, one of the suspected sources, suggests an origin before the development of synthetic quinolones. However, their native function remains unknown. Previous work indicated that expression of qnrVv in V. vulnificus was induced by cold shock. To investigate its role further, we constructed single in-frame deletion mutants in qnrVv and cspA (the gene for cold shock protein) and a double mutant in qnrVv and cspA in V. vulnificus ATCC 17562 to evaluate the response to different environmental conditions and stresses and to exposure to various DNA-damaging agents. We found that qnrVv is in

SUBMITTER: Gil-Marques ML 

PROVIDER: S-EPMC8316120 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature