CCL19 enhances CD8⁺ T-cell responses and accelerates HBV clearance.

ABSTRACT:

Background

Chemokine (C-C motif) ligand 19 (CCL19) is a leukocyte chemoattractant that plays a crucial role in cell trafficking and leukocyte activation. Dysfunctional CD8⁺ T cells play a crucial role in persistent HBV infection. However, whether HBV can be cleared by CCL19-activated immunity remains unclear.

Methods

We assessed the effects of CCL19 on the activation of PBMCs in patients with HBV infection. We also examined how CCL19 influences HBV clearance and modulates HBV-responsive T cells in a mouse model of chronic hepatitis B (CHB). In addition, C-C chemokine-receptor type 7 (CCR7) knockdown mice were used to elucidate the underlying mechanism of CCL19/CCR7 axis-induced immune activation.

Results

From in vitro experiments, we found that CCL19 enhanc

SUBMITTER: Yan Y 

PROVIDER: S-EPMC8316179 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature