Nonesterified Fatty Acids and Kidney Function Decline in Older Adults: Findings From the Cardiovascular Health Study.

ABSTRACT:

Rationale & objective

Circulating nonesterified fatty acids (NEFAs) make up a small portion of circulating lipids but are a metabolically important energy source. Excessive circulating NEFAs may contribute to lipotoxicity in many tissues, including the kidneys. We investigated the relationship between total circulating NEFA concentration and kidney outcomes in older, community-dwelling adults.

Study design

Prospective cohort study.

Setting & participants

4,698 participants≥65 years of age in the Cardiovascular Health Study who underwent total fasting serum NEFA concentration measurements in 1992-1993.

Exposure

Fasting serum NEFA concentration at one time point.

Outcome

Three primary outcomes: estimated glomerular filtration rate (eGFR) decline of≥30%, th

SUBMITTER: Walther CP 

PROVIDER: S-EPMC8316278 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature