Association of Coronary Artery Atherosclerosis With Brain White Matter Hyperintensity.

ABSTRACT:

Background and purpose

We aim to determine, in healthy high-risk adults, the association between subclinical coronary artery disease and white matter hyperintensity (WMH) volume and location, independent of atherosclerotic risk factors.

Methods

Seven hundred eighty-two asymptomatic first-degree relatives of index cases with early-onset coronary artery disease (<60 years old) from GeneSTAR (Genetic Study of Atherosclerosis Risk) with contemporaneous coronary computed tomography angiography and brain magnetic resonance imaging were analyzed. Multilevel mixed-effects linear regression models, accounting for family structure, evaluated the association of total WMH volume and 3 regions (deep WMH, periventricular WMH [PVWMH], or borderzone [cuff]) with markers of coronary artery d

SUBMITTER: Johansen MC 

PROVIDER: S-EPMC8316285 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature