Cognitive Impairment and Dementia After Stroke: Design and Rationale for the DISCOVERY Study.

ABSTRACT: Stroke is a leading cause of the adult disability epidemic in the United States, with a major contribution from poststroke cognitive impairment and dementia (PSCID), the rates of which are disproportionally high among the health disparity populations. Despite the PSCID's overwhelming impact on public health, a knowledge gap exists with regard to the complex interaction between the acute stroke event and highly prevalent preexisting brain pathology related to cerebrovascular and Alzheimer disease or related dementia. Understanding the factors that modulate PSCID risk in relation to index stroke event is critically important for developing personalized prognostication of PSCID, targeted interventions to prevent it, and for informing future clinical trial design. The DISCOVERY study (Determin

SUBMITTER: Rost NS 

PROVIDER: S-EPMC8316324 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature