Delta oscillation underlies the interictal spike changes after repeated transcranial direct current stimulation in a rat model of chronic seizures.

ABSTRACT:

Background

Transcranial direct current stimulation (tDCS) provides a noninvasive polarity-specific constant current to treat epilepsy, through a mechanism possibly involving excitability modulation and neural oscillation.

Objective

To determine whether EEG oscillations underlie the interictal spike changes after tDCS in rats with chronic spontaneous seizures.

Methods

Rats with kainic acid-induced spontaneous seizures were subjected to cathodal tDCS or sham stimulation for 5 consecutive days. Video-EEG recordings were collected immediately pre- and post-stimulation and for the subsequent 2 weeks following stimulation. The acute pre-post stimulation and subacute follow-up changes of interictal spikes and EEG oscillations in tDCS-treated rats were compared with sham. Ict

SUBMITTER: Wu YJ 

PROVIDER: S-EPMC8316371 | biostudies-literature | 2021 Jul-Aug

REPOSITORIES: biostudies-literature