A randomized trial of exercise and diet on body composition in survivors of breast cancer with overweight or obesity.

ABSTRACT:

Purpose

Obesity increases the risk of cancer recurrence and death in survivors of breast cancer. This study tested the hypothesis that exercise alone, diet alone, and the combination of exercise plus diet reduce body weight and improve body composition in survivors of breast cancer.

Methods

In this 2 × 2 factorial trial, 351 survivors of breast cancer with overweight or obesity were randomized to one of four treatment groups for 52 weeks: control, exercise alone, diet alone, or exercise plus diet. Endpoints included body weight and body composition measured by dual-energy x-ray absorptiometry.

Results

After 52 weeks, compared with control, diet alone [- 5.39 kg (95% CI - 7.24, - 3.55);- 6.0% (95% CI - 8.0, - 3.9)] and exercise plus diet [- 6.68 kg (95% CI - 8.46, - 4.

SUBMITTER: Brown JC 

PROVIDER: S-EPMC8316406 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature