Ontology highlight
ABSTRACT:
SUBMITTER: Bou-Nader C
PROVIDER: S-EPMC8316439 | biostudies-literature | 2021 Jul
REPOSITORIES: biostudies-literature
Bou-Nader Charles C Stull Frederick W FW Pecqueur Ludovic L Simon Philippe P Guérineau Vincent V Royant Antoine A Fontecave Marc M Lombard Murielle M Palfey Bruce A BA Hamdane Djemel D
Nature communications 20210727 1
Folate enzyme cofactors and their derivatives have the unique ability to provide a single carbon unit at different oxidation levels for the de novo synthesis of amino-acids, purines, or thymidylate, an essential DNA nucleotide. How these cofactors mediate methylene transfer is not fully settled yet, particularly with regard to how the methylene is transferred to the methylene acceptor. Here, we uncovered that the bacterial thymidylate synthase ThyX, which relies on both folate and flavin for act ...[more]