Tracing Lung Cancer Risk Factors Through Mutational Signatures in Never-Smokers.

ABSTRACT: Epidemiologic studies often rely on questionnaire data, exposure measurement tools, and/or biomarkers to identify risk factors and the underlying carcinogenic processes. An emerging and promising complementary approach to investigate cancer etiology is the study of somatic "mutational signatures" that endogenous and exogenous processes imprint on the cellular genome. These signatures can be identified from a complex web of somatic mutations thanks to advances in DNA sequencing technology and analytical algorithms. This approach is at the core of the Sherlock-Lung study (2018-ongoing), a retrospective case-only study of over 2,000 lung cancers in never-smokers (LCINS), using different patterns of mutations observed within LCINS tumors to trace back possible exposures or endogenous processes

SUBMITTER: Landi MT 

PROVIDER: S-EPMC8316614 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature