Tanshinol Alleviates Microcirculation Disturbance and Impaired Bone Formation by Attenuating TXNIP Signaling in GIO Rats.

ABSTRACT: Impaired bone formation is the main characteristics of glucocorticoid (GC)-induced osteoporosis (GIO), which can be ameliorated by tanshinol, an aqueous polyphenol isolated from Salvia miltiorrhiza Bunge. However, the underlying mechanism is still not entirely clear. In the present study, we determined the parameters related to microstructure and function of bone tissue, bone microcirculation, and TXNIP signaling to investigate the beneficial effects of tanshinol on skeleton and its molecular mechanism in GIO rats. Male Sprague-Dawley rats aged 4 months were administrated orally with distilled water (Con), tanshinol (Tan, 25 mg kg^-1 d^-1), prednisone (GC, 5 mg kg^-1 d^-1) and GC plus tanshinol (GC + Tan) for 14 weeks. The results demonstrated

SUBMITTER: Lai W 

PROVIDER: S-EPMC8316650 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature