Thrombomodulin expression impacts the recurrence and long-term survival in pancreatic cancer.

ABSTRACT:

Background

Pancreatic cancer is one of the most aggressive digestive cancers. The tumor expression of thrombomodulin (TM) is correlated with favorable prognosis in several types of cancer. However, this correlation has not been confirmed in hepato-pancreato-biliary cancer. The aim of this study was to evaluate the prognostic value of TM expression in resected pancreatic ductal adenocarcinoma.

Methods

The data of patients who underwent pancreatic resection for pancreatic invasive ductal adenocarcinoma were obtained from a prospectively maintained database. A total of 131 patients were included. Paraffin sections of tumor tissues were stained immunohistochemically using TM antibody. The patients were divided into two groups: the TM-positive or TM-negative group.

Results

SUBMITTER: Sugano H 

PROVIDER: S-EPMC8316731 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature