Cortical Thickness and Hippocampal Volume in Vascular and Non-vascular Depressed Patients.

ABSTRACT: Background: Reduced cortical thickness and hippocampal volume are prevalent markers of late life depression as well as mild cognitive impairment (MCI) but are conspicuously absent in the vascular depression (VD) literature. The present study aimed to determine differences in cortical thickness and hippocampal volume between VD and non-VD patients. Methods: Participants were enrolled in an 8-week open treatment antidepressant trial. Forty-one depressed individuals aged 50 and older underwent brain magnetic resonance imaging at baseline and were classified as VD or non-VD. Cortical thickness values for the left and right entorhinal, parahippocampal, and precuneal cortices, as well as left and right hippocampal volume, were linearly regressed on VD status to determine mean diffe

SUBMITTER: Egglefield DA 

PROVIDER: S-EPMC8316761 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature