Comparing Host Module Activation Patterns and Temporal Dynamics in Infection by Influenza H1N1 Viruses.

ABSTRACT: Influenza is a serious global health threat that shows varying pathogenicity among different virus strains. Understanding similarities and differences among activated functional pathways in the host responses can help elucidate therapeutic targets responsible for pathogenesis. To compare the types and timing of functional modules activated in host cells by four influenza viruses of varying pathogenicity, we developed a new DYNAmic MOdule (DYNAMO) method that addresses the need to compare functional module utilization over time. This integrative approach overlays whole genome time series expression data onto an immune-specific functional network, and extracts conserved modules exhibiting either different temporal patterns or overall transcriptional activity. We identified a common core resp

SUBMITTER: Nudelman I 

PROVIDER: S-EPMC8317020 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature