Ribosome occupancy profiles are conserved between structurally and evolutionarily related yeast domains.

ABSTRACT:

Motivation

Protein synthesis is a non-equilibrium process, meaning that the speed of translation can influence the ability of proteins to fold and function. Assuming that structurally similar proteins fold by similar pathways, the profile of translation speed along an mRNA should be evolutionarily conserved between related proteins to direct correct folding and downstream function. The only evidence to date for such conservation of translation speed between homologous proteins has used codon rarity as a proxy for translation speed. There are, however, many other factors including mRNA structure and the chemistry of the amino acids in the A- and P-sites of the ribosome that influence the speed of amino acid addition.

Results

Ribosome profiling experiments provide a signal dir

SUBMITTER: Nissley DA 

PROVIDER: S-EPMC8317121 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature