Neuromuscular Blockade and Reversal Agent Practice Variability in the US Inpatient Surgical Settings.

ABSTRACT:

Introduction

The management of neuromuscular blockade (NMB) has evolved over time and remains a critical component of general anesthesia. However, NMB use varies by patient and procedural characteristics, clinical practices, protocols, and drug access. National utilization patterns are unknown. We describe changes in NMB and NMB reversal agent administration in surgical inpatients since the US introduction of sugammadex in December 2015.

Methods

In a retrospective observational study of inpatients involving NMB with rocuronium or vecuronium in the Premier Healthcare Database, we estimate associations between factors related to choice of (1) active NMB reversal versus spontaneous recovery and (2) sugammadex versus neostigmine as the reversal agent.

Results

Among 4.3 mi

SUBMITTER: Bash LD 

PROVIDER: S-EPMC8317140 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature