Clinical outcomes and patterns of failure of head and neck mucosal melanoma treated with multiple treatment modalities.

ABSTRACT:

Objectives

The study aims to analyze the clinical characteristics of head and neck mucosal melanoma (MMHN) and the effects of multiple treatment modalities on distant metastasis, recurrence and survival rates to provide a reference for the individualized treatment of MMHN.

Methods

We retrospectively reviewed 262 patients with stage III-IVb MMHN treated from March 1986 to November 2018 at our cancer center.

Results

The median follow-up time was 34.0 months (range 1-262 months). The 5-year overall survival (OS), distant metastasis-free survival (DMFS) and disease-free survival (DFS) probabilities were 37.7%, 30.2%, and 20.3%, respectively. The 5-year OS rates for patients with stage III, stage IVA, and stage IVB MMHN were 67.0%, 24.1% and 8.3%, respectively (P < 0.001).

SUBMITTER: Xu QQ 

PROVIDER: S-EPMC8317323 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature