Characterization of the blood-brain barrier in genetically diverse laboratory mouse strains.

ABSTRACT:

Background

Genetic variation in a population has an influence on the manifestation of monogenic as well as multifactorial disorders, with the underlying genetic contribution dependent on several interacting variants. Common laboratory mouse strains used for modelling human disease lack the genetic variability of the human population. Therefore, outcomes of rodent studies show limited relevance to human disease. The functionality of brain vasculature is an important modifier of brain diseases. Importantly, the restrictive interface between blood and brain-the blood-brain barrier (BBB) serves as a major obstacle for the drug delivery into the central nervous system (CNS). Using genetically diverse mouse strains, we aimed to investigate the phenotypic and transcriptomic variation of t

SUBMITTER: Schaffenrath J 

PROVIDER: S-EPMC8317333 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature