Analysis of therapeutic targets and prognostic biomarkers of CXC chemokines in cervical cancer microenvironment.

ABSTRACT:

Background

The tumor microenvironment (TME) has received an increasing amount of attention. CXC chemokines can regulate immune cell transport and tumor cell activity to exert anti-tumor immunity. However, studies on the expression and prognosis of CXC chemokines in cervical cancer (CC) are more limited.

Methods

The study investigated the role of CXC chemokines in TME of CC by using public databases. Moreover, quantitative real-time PCR (qRT-PCR) and immunohistochemistry (IHC) of CXC chemokines were performed to further verify.

Results

The transcriptional levels of CXCL1/3/5/6/8/9/10/11/13/16/17 in CC tissues were significantly elevated while the transcriptional levels of CXCL12/14 were significantly reduced. We reached a consistent conclusion that the expression of CX

SUBMITTER: Kong W 

PROVIDER: S-EPMC8317415 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature