Genome-Wide MicroRNA Analysis of Peripheral Blood Mononuclear Cells Reveals Elevated miR-142-3p Expression as a Potential Biomarker for Secondary Syphilis.

ABSTRACT:

Background

Treponema pallidum subspecies pallidum (T. pallidum) infection induces significant immune responses, resulting in tissue damage. Gene expression plays an essential role in regulating the progression of syphilis infection. However, little is known about the regulatory role of microRNAs (miRNAs) in the immune response to T. pallidum infection. Here, we analyze the differential expression of miRNAs in peripheral blood mononuclear cells (PBMCs) between untreated secondary syphilis patients and healthy controls and study the correlation between miRNA expression and clinical features with bioinformatics.

Methods

The expression profile of miRNAs was measured by microarray analysis in PBMCs of untreated secondary syphilis patients

SUBMITTER: Yang Z 

PROVIDER: S-EPMC8317471 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature