A Metabolomic Signature of Glucagon Action in Healthy Individuals With Overweight/Obesity.

ABSTRACT:

Context

Glucagon is produced and released from the pancreatic alpha-cell to regulate glucose levels during periods of fasting. The main target for glucagon action is the liver, where it activates gluconeogenesis and glycogen breakdown; however, glucagon is postulated to have other roles within the body.

Objective

We sought to identify the circulating metabolites that would serve as markers of glucagon action in humans.

Methods

In this study (NCT03139305), we performed a continuous 72-hour glucagon infusion in healthy individuals with overweight/obesity. Participants were randomized to receive glucagon 12.5 ng/kg/min (GCG 12.5), glucagon 25 ng/kg/min (GCG 25), or a placebo control. A comprehensive metabolomics analysis was then performed from plasma isolated at several

SUBMITTER: Vega RB 

PROVIDER: S-EPMC8317630 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature