Genetic Susceptibility for Low Testosterone in Men and Its Implications in Biology and Screening: Data from the UK Biobank.

ABSTRACT:

Background

Despite strong evidence of heritability, few studies have attempted to unveil the genetic underpinnings of testosterone levels.

Objective

To identify testosterone-associated loci in a large study and assess their biological and clinical implications.

Design setting and participants

The participants were men from the UK Biobank. A two-stage genome-wide association study (GWAS) was first used to identify/validate loci for low testosterone (LowT, <8 nmol/l) in 80% of men (N = 148 902). The cumulative effect of independent LowT risk loci was then evaluated in the remaining 20% of men.

Outcome measurements and statistical analysis

Associations of single nucleotide polymorphisms (SNPs) with LowT were tested using an additive model. Analyses of the e

SUBMITTER: Fantus RJ 

PROVIDER: S-EPMC8317803 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature